Real-World Predictors of Severe Neutropenia Associated with Palbociclib and Endocrine Therapy for Metastatic Breast Cancer in Japanese Patients

Author:

Takada Shinya1,Maeda Hideki2,Umehara Kengo1,Kuwahara Sayuri2,Yamamoto Mitsugu2,Tomioka Nobumoto2,Watanabe Kenichi2,Mino Kozo1

Affiliation:

1. Department of Pharmacy, National Hospital Organization Hokkaido Cancer Center

2. Department of Breast Surgery, National Hospital Organization Hokkaido Cancer Center

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference31 articles.

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2. 2) Finn RS, Martin M, Rugo HS, Jones S, Im SA, Gelmon K, Harbeck N, Lipatov ON, Walshe JM, Moulder S, Gauthier E, Lu DR, Randolph S, Diéras V, Slamon DJ. Palbociclib and letrozole in advanced breast cancer. N. Engl. J. Med., 375, 1925–1936 (2016).

3. 3) Thein KZ, Htut TW, Ball S, Swarup S, Sultan A, Oo TH. Venous thromboembolism risk in patients with hormone receptor-positive HER2-negative metastatic breast cancer treated with combined CDK 4/6 inhibitors plus endocrine therapy versus endocrine therapy alone: a systematic review and meta-analysis of randomized controlled trials. Breast Cancer Res. Treat., 183, 479–487 (2020).

4. 4) Rugo HS, Finn RS, Gelmon K, Joy AA, Harbeck N, Castrellon A, Mukai H, Walshe JM, Mori A, Gauthier E, Lu DR, Bananis E, Martin M, Diéras V. Progression-free survival outcome is independent of objective response in patients with estrogen receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer treated with palbociclib plus letrozole compared with letrozole: analysis from PALOMA-2. Clin. Breast Cancer, 20, e173–e180 (2020).

5. 5) Diéras V, Rugo HS, Schnell P, Gelmon K, Cristofanilli M, Loi S, Colleoni M, Lu DR, Mori A, Gauthier E, Huang Bartlett C, Slamon DJ, Turner NC, Finn RS. Long-term pooled safety analysis of palbociclib in combination with endocrine therapy for HR +/HER2- advanced breast cancer. J. Natl. Cancer Inst., 111, 419–430 (2019).

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