Novel Screening System for Biliary Excretion of Drugs Using Human Cholangiocyte Organoid Monolayers with Directional Drug Transport-Reference-Cited by-同舟云学术

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Novel Screening System for Biliary Excretion of Drugs Using Human Cholangiocyte Organoid Monolayers with Directional Drug Transport

Published:2024-02-16 Issue:2 Volume:47 Page:427-433
ISSN:0918-6158
Container-title:Biological and Pharmaceutical Bulletin
language:en
Short-container-title:Biological & Pharmaceutical Bulletin

Author:

Mizoi Kenta¹²,Okada Ryo³,Mashimo Arisa¹⁴,Masuda Norio⁵,Itoh Manabu³,Ishida Seiichi⁶,Yamazaki Daiju⁷,Ogihara Takuo¹⁸

Affiliation:

1. Faculty of Pharmacy, Takasaki University of Health and Welfare

2. School of Pharmacy, International University of Health and Welfare

3. JSR-Keio University Medical and Chemical Innovation Center (JKiC), JSR Corporation

4. Kendai Translational Research Center (KTRC)

5. MEDICAL & BIOLOGICAL LABORATORIES CO., LTD. (MBL)

6. Division of Applied Life Science, Graduate School of Engineering, Sojo University

7. Division of Pharmacology, Center for Biological Safety and Research, National Institute of Health Sciences

8. Graduate School of Pharmaceutical Sciences, Takasaki University of Health and Welfare

Publisher

Pharmaceutical Society of Japan

Link

https://www.jstage.jst.go.jp/article/bpb/47/2/47_b23-00655/_pdf

Reference47 articles.

1. 1) Ishida S. Organs-on-a-chip:current applications and consideration points for in-vitro ADME-Tox studies. Drug Metab. Pharmacokinet., 33, 49–54 (2018).

2. 2) Mizoi K, Arakawa H, Yano K, Koyama S, Kojima H, Ogihara T. Utility of three-dimensional cultures of primary human hepatocytes (spheroids) as pharmacokinetic models. Biomedicines, 8, 374 (2020).

3. 3) Emoto C, Murayama N, Rostami-Hodjegan A, Yamazaki H. Methodologies for investigating drug metabolism at the early drug discovery stage: prediction of hepatic drug clearance and P450 contribution. Curr. Drug Metab., 11, 678–685 (2010).

4. 4) Naritomi Y, Sanoh S, Ohta S. Chimeric mice with humanized liver: application in drug metabolism and pharmacokinetics studies for drug discovery. Drug Metab. Pharmacokinet., 33, 31–39 (2018).

5. 5) Suzuyama N, Katoh M, Takeuchi T, Yoshitomi S, Higuchi T, Asashi S, Yokoi T. Species differences of inhibitory effects on P-glycoprotein-mediated drug transport. J. Pharm. Sci., 96, 1609–1618 (2007).

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