Effect of Growth Hormone Receptor Deficiency on Androgen-Associated Gene Expression of Hepatic Drug Metabolizing Enzymes and Drug Transporters in Pigs-Reference-Cited by-同舟云学术

Effect of Growth Hormone Receptor Deficiency on Androgen-Associated Gene Expression of Hepatic Drug Metabolizing Enzymes and Drug Transporters in Pigs

Published:2023-09-01 Issue:9 Volume:46 Page:1338-1342
ISSN:0918-6158
Container-title:Biological and Pharmaceutical Bulletin
language:en
Short-container-title:Biological & Pharmaceutical Bulletin

Author:

Kojima Misaki¹,Fuchimoto Daiichiro²,Yamashita Shiro³,Onishi Akira⁴,Degawa Masakuni⁵,Nemoto Kiyomitsu⁶

Affiliation:

1. Meat Animal Biosystem Group, Division of Meat Animal and Poultry Research, Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO)

2. Animal Model Development Group, Division of Biomaterial Sciences, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization (NARO)

3. Quality Control Research Section, Central Research Institute for Feed and Livestock, Zen-noh

4. Department of Animal Science and Resources, College of Bioresource Sciences, Nihon University

5. Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka

6. Department of Molecular Toxicology, Faculty of Pharmaceutical Sciences, Toho University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

https://www.jstage.jst.go.jp/article/bpb/46/9/46_b23-00237/_pdf

Reference16 articles.

1. 1) Tang H, Mayersohn M. Porcine prediction of pharmacokinetic parameters in people: a pig in a poke? Drug Metab. Dispos., 46, 1712–1724 (2018).

2. 2) Lunney JK, Van Goor A, Walker KE, Hailstock T, Franklin J, Dai C. Importance of the pigs as a human biomedical model. Sci. Transl. Med., 13, eabd5758 (2021).

3. 3) Hinrichs A, Kessler B, Kurome M, Blutke A, Kemter E, Bernau M, Scholz AM, Rathkolb B, Renner S, Bultmann S, Leonhardt H, de Angelis MH, Nagashima H, Hoeflich A, Blum WF, Bidlingmaier M, Wanke R, Dahlhoff M, Wolf E. Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver. Mol. Metab., 11, 113–128 (2018).

4. 4) Kojima M. Sex and breed differences in the constitutive gene expression of hepatic drug metabolizing1 enzymes in Meishan and Landrace pigs: testosterone-mediated differences. Jpn. Agric. Res. Q., 54, 7–12 (2020).

5. 5) Kojima M, Degawa M. Androgen-dependent differences in the amounts of CYP mRNAs in the pig kidney. Biol. Pharm. Bull., 44, 1120–1128 (2021).