Hydroxytyrosol Alleviates Methotrexate-Induced Pulmonary Fibrosis in Rats: Involvement of TGF-β1, Tissue Factor, and VEGF
Author:
Affiliation:
1. Department of Pharmacology, Egyptian Drug Authority (EDA), formerly known as National Organization for Drug Control and Research
2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University
Publisher
Pharmaceutical Society of Japan
Link
https://www.jstage.jst.go.jp/article/bpb/47/1/47_b23-00477/_pdf
Reference40 articles.
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2. 2) Ohbayashi M, Suzuki M, Yashiro Y, Fukuwaka S, Yasuda M, Kohyama N, Kobayashi Y, Yamamoto T. Induction of pulmonary fibrosis by methotrexate treatment in mice lung in vivo and in vitro. J. Toxicol. Sci., 35, 653–661 (2010).
3. 3) Arpag H, Gül M, Aydemir Y, Atilla N, Yiğitcan B, Cakir T, Polat C, Þehirli Ö, Sayan M. Protective effects of alpha-lipoic acid on methotrexate-induced oxidative lung injury in rats. J. Invest. Surg., 31, 107–113 (2018).
4. 4) Wynn TA. Integrating mechanisms of pulmonary fibrosis. J. Exp. Med., 208, 1339–1350 (2011).
5. 5) Moss BJ, Ryter S, Rosas I. Pathogenic mechanisms underlying idiopathic pulmonary fibrosis. Annu. Rev. Pathol., 17, 515–546 (2022).
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