Osteoblastgenic and Osteogenic Effects of KY-273 with CDK8/19 Inhibitory Activity in Bone Marrow Mesenchymal Stem Cells and Female Rats
Author:
Affiliation:
1. United Graduate School of Drug Discovery and Medical Information Science, Gifu University
2. R&D Division, Kyoto Pharmaceutical Industries, Ltd.
3. Department of Bioactive Molecules, Pharmacology, Gifu Pharmaceutical University
Publisher
Pharmaceutical Society of Japan
Link
https://www.jstage.jst.go.jp/article/bpb/47/3/47_b23-00834/_pdf
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3. 3) Guo HF, Shao HY, Yang ZY, Xue ST, Li X, Liu ZY, He XB, Jiang JD, Zhang YQ, Si SY, Li ZR. Substituted benzothiophene or benzofuran derivatives as a novel class of bone morphogenetic protein-2 up-regulators: synthesis, structure–activity relationships, and preventive bone loss efficacies in senescence accelerated mice (SAMP6) and ovariectomized rats. J. Med. Chem., 53, 1819–1829 (2010).
4. 4) Kuo PL, Huang YT, Chang CH, Chang JK. Bone morphogenetic protein-2 and -4 (BMP-2 and -4) mediates fraxetin-induced maturation and differentiation in human osteoblast-like cell lines. Biol. Pharm. Bull., 29, 119–124 (2006).
5. 5) Liu S, Luo ZH, Ji GM, Guo W, Cai JZ, Fu LC, Zhou J, Hu YJ, Shen XL. Cajanolactone a from cajanus cajan promoted osteoblast differentiation in human bone marrow mesenchymal stem cells via stimulating Wnt/LRP5/β-Catenin signaling. Molecules, 24, 271 (2019).
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