Identification of Y118 Amino Acid Residue in Candida albicans Sterol 14.ALPHA.-Demethylase Associated with the Enzyme Activity and Selective Antifungal Activity of Azole Analogues-Reference-Cited by-同舟云学术

Identification of Y118 Amino Acid Residue in Candida albicans Sterol 14.ALPHA.-Demethylase Associated with the Enzyme Activity and Selective Antifungal Activity of Azole Analogues

Published:2007 Issue:7 Volume:30 Page:1246-1253
ISSN:0918-6158
Container-title:Biological and Pharmaceutical Bulletin
language:en
Short-container-title:Biol. Pharm. Bull.

Author:

Chen Shuang-Hong¹,Sheng Chun-Quan²,Xu Xiao-Hui³,Jiang Yuan-Ying²,Zhang Wan-Nian²,He Cheng³

Affiliation:

1. Naval Medical Research Institute

2. School of Pharmacy, Second Military Medical University

3. Department of Neurobiology, Second Military Medical University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

http://www.jstage.jst.go.jp/article/bpb/30/7/30_7_1246/_pdf

Reference33 articles.

1. Molecular basis of resistance to azole antifungals

2. Conservation in the CYP51 Family. Role of the B‘ Helix/BC Loop and Helices F and G in Enzymatic Function

3. A Three-Dimensional Model of Lanosterol 14α-Demethylase of Candida albicans and Its Interaction with Azole Antifungals

4. Molecular Modelling of Lanosterol 14α-Demethylase (CYPSl) fromSaccharomyces Cerevisiaevia Homology with CYP102, a Unique Bacterial Cytochrome P450 Isoform: Quantitative Structure-Activity Relationships (QSARs) within two Related Series of Antifungal Azole Derivatives

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