The Antibiotic Cefotaxime Works as Both an Activator of Nrf2 and an Inducer of HSP70 in Mammalian Cells

Author:

Yamada Mayuka1,Suzuki Midori1,Noguchi Takuya1,Yokosawa Takumi1,Sekiguchi Yuto1,Mutoh Natsumi1,Toyama Takashi2,Hirata Yusuke1,Hwang Gi-Wook2,Matsuzawa Atsushi1

Affiliation:

1. Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University

2. Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University

Publisher

Pharmaceutical Society of Japan

Subject

General Medicine

Reference27 articles.

1. 1) Jones RN. Cefotaxime and desacetylcefotaxime antimicrobial interactions. The clinical relevance of enhanced activity: a review. Diagn. Microbiol. Infect. Dis., 22, 19–33 (1995).

2. 2) Chatterjee S, Mandal A, Lyle N, Mukherjee S, Singh AK. Drug utilization study in a neonatology unit of a tertiary care hospital in eastern India. Pharmacoepidemiol. Drug Saf., 16, 1141–1145 (2007).

3. 3) Fujino G, Noguchi T, Takeda K, Ichijo H. Thioredoxin and protein kinases in redox signaling. Semin. Cancer Biol., 16, 427–435 (2006).

4. 4) Suzuki T, Yamamoto M. Molecular basis of the Keap1-Nrf2 system. Free Radic. Biol. Med., 88, 93–100 (2015).

5. 5) Vriend J, Reiter RJ. The Keap1-Nrf2-antioxidant response element pathway: a review of its regulation by melatonin and the proteasome. Mol. Cell. Endocrinol., 401, 213–220 (2015).

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