Novel Quinolinylaminoisoquinoline Bioisosteres of Sorafenib as Selective RAF1 Kinase Inhibitors: Design, Synthesis, and Antiproliferative Activity against Melanoma Cell Line

Author:

Cho Hye Jung12,El-Gamal Mohammed Ibrahim345,Oh Chang-Hyun34,Lee So Ha1,Sim Taebo1,Kim Garam6,Choi Hong Seok6,Choi Jung Hoon2,Yoo Kyung Ho1

Affiliation:

1. Chemical Kinomics Research Center, Korea Institute of Science and Technology

2. Department of Chemistry, Hanyang University

3. Center for Biomaterials, Korea Institute of Science and Technology

4. Department of Biomolecular Science, University of Science and Technology

5. Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura

6. College of Pharmacy, Chosun University

Publisher

Pharmaceutical Society of Japan

Subject

Drug Discovery,General Chemistry,General Medicine

Reference28 articles.

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2. 2) Pollock P. M., Meltzer P. S., Nature (London), 417, 906–907 (2002).

3. 3) Tuveson D. A., Weber B. L., Herlyn M., Cancer Cell, 4, 95–98 (2003).

4. 4) Garbe C., Hauschild A., Volkenandt M., Schadendorf D., Stolz W., Reinhold U., Kortmann R. D., Kettelhack C., Frerich B., Keilholz U., Dummer R., Sebastian G., Tilgen W., Schuler G., Mackensen A., Kaufmann R., Melanoma Res., 17, 393–399 (2007).

5. 5) Atallah E., Flaherty L., Curr. Treat. Options Oncol., 6, 185–193 (2005).

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