Triptolide Suppresses Growth of Breast Cancer by Targeting HMGB1 in Vitro and in Vivo

Author:

Jiang Wei1,Chen Maojian2,Xiao Chanchan3,Yang Weiping2,Qin Qinghong2,Tan Qixing2,Liang Zhijie4,Liao Xiaoli1,Mao Anyun2,Wei Changyuan2

Affiliation:

1. Department of Medical Oncology, The Affiliated Tumor Hospital of Guangxi Medical University

2. Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University

3. Department of Experimental Research, The Affiliated Tumor Hospital of Guangxi Medical University

4. Department of Breast and Thyroid Surgery, The Fifth Affliated Hospital of Guangxi Medical University & The First People’s Hospital of Nanning

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference48 articles.

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2. 2) Davies C, Pan H, Godwin J, Gray R, Arriagada R, Raina V, Abraham M, Medeiros Alencar VH, Badran A, Bonfill X, Bradbury J, Clarke M, Collins R, Davis SR, Delmestri A, Forbes JF, Haddad P, Hou MF, Inbar M, Khaled H, Kielanowska J, Kwan WH, Mathew BS, Mittra I, Muller B, Nicolucci A, Peralta O, Pernas F, Petruzelka L, Pienkowski T, Radhika R, Rajan B, Rubach MT, Tort S, Urrutia G, Valentini M, Wang Y, Peto R. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet, 381, 805–816 (2013).

3. 3) Chen SR, Dai Y, Zhao J, Lin L, Wang Y, Wang Y. A mechanistic overview of triptolide and celastrol, natural products from Tripterygium wilfordii Hook F. Frontiers in Pharmacology, 9, 104 (2018).

4. 4) Xi C, Peng S, Wu Z, Zhou Q, Zhou J. Toxicity of triptolide and the molecular mechanisms involved. Biomed. Pharmacother., 90, 531–541 (2017).

5. 5) Meng C, Zhu H, Song H, Wang Z, Huang G, Li D, Ma Z, Ma J, Qin Q, Sun X, Ma J. Targets and molecular mechanisms of triptolide in cancer therapy. Chin. J. Cancer Res., 26, 622–626 (2014).

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