Defensive Effects of a Unique Polysaccharide, Sacran, to Protect Keratinocytes against Extracellular Stimuli and Its Possible Mechanism of Action

Author:

Doi Moeko1,Sagawa Yuki2,Tanaka Takumi1,Mizutani Taeko2,Okano Yuri2,Masaki Hitoshi2

Affiliation:

1. DAITO KASEI KOGYO Co., Ltd.

2. Tokyo University of Technology Graduate School, Department of Bionics

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference23 articles.

1. 1) Boguniewicz M, Leung DY. Atopic dermatitis: A disease of altered skin barrier and immune dysregulation. Immunol. Rev., 242, 233–246 (2011).

2. 2) Imokawa G, Ishida K. Role of ceramide in the barrier function of the stratum corneum, implications for the pathogenesis of atopic dermatitis. J. Clin. Exp. Dermatol. Res., 5, 206 (2014).

3. 3) Kamide R, Misery L, Perez-Cullell N, Sibaud V, Taïeb C. Sensitive skin evaluation in the Japanese population. J. Dermatol., 40, 177–181 (2013).

4. 4) Richters RJH, Falcone D, Uzunbajakava NE, Varghese B, Caspers PJ, Puppels GJ, van Erp PEJ, van de Kerkhof PCM. Sensitive skin: assessment of the skin barrier using confocal Raman microspectroscopy. Skin Pharmacol. Physiol., 30, 1–12 (2017).

5. 5) Okajima MK, Ono M, Kabata K, Kaneko T. Extraction of novel sulfated polysacchardes from Aphanothece sacrum, and its spectroscopic characterization. Pure Appl. Chem., 79, 2039–2046 (2007).

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