Curcumin Down-Regulates Toll-Like Receptor-2 Gene Expression and Function in Human Cystic Fibrosis Bronchial Epithelial Cells

Author:

Chaudhary Niraj12,Ueno-Shuto Keiko3,Ono Tomomi1,Ohira Yuko1,Watanabe Kenji4,Nasu Aoi1,Fujikawa Haruka12,Nakashima Ryunosuke1,Takahashi Noriki1,Suico Mary Ann1,Kai Hirofumi1,Shuto Tsuyoshi1

Affiliation:

1. Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University

2. Program for Leading Graduate School of “HIGO (Health Life Science: Interdisciplinary and Global Oriented) Program,” Kumamoto University

3. Laboratory of Pharmacology, Division of Life Science, Faculty of Pharmaceutical Sciences, Sojo University

4. Institute of Gene Research, Yamaguchi University Science Research Center

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference28 articles.

1. 1) Elborn JS. Cystic fibrosis. Lancet, 388, 2519–2531 (2016).

2. 2) Haq IJ, Gray MA, Garnett JP, Ward C, Brodlie M. Airway surface liquid homeostasis in cystic fibrosis: Pathophysiology and therapeutic targets. Thorax, 71, 284–287 (2016).

3. 3) Muir A, Soong G, Sokol S, Reddy B, Gomez MI, Van Heeckeren A, Prince A. Toll-like receptors in normal and cystic fibrosis airway epithelial cells. Am. J. Respir. Cell Mol. Biol., 30, 777–783 (2004).

4. 4) Firoved AM, Ornatowski W, Deretic V. Microarray analysis reveals induction of lipoprotein genes in mucoid Pseudomonas aeruginosa: implications for inflammation in cystic fibrosis. Infect. Immun., 72, 5012–5018 (2004).

5. 5) Shuto T, Furuta T, Oba M, Xu H, Li J-D, Cheung J, Gruenert DC, Uehara A, Suico MA, Okiyoneda T, Kai H. Promoter hypomethylation of Toll-like receptor-2 gene is associated with increased proinflammatory response toward bacterial peptidoglycan in cystic fibrosis bronchial epithelial cells. FASEB J., 20, 782–784 (2006).

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