Effects of Zoledronate on Local and Systemic Production of IL-1β, IL-18, and TNF-α in Mice and Augmentation by Lipopolysaccharide

Author:

Funayama Hiromi1,Tashima Itaru1,Okada Satoru2,Ogawa Takuya3,Yagi Hideki4,Tada Hiroyuki5,Wakita Ryo6,Asada Yoshinobu1,Endo Yasuo2

Affiliation:

1. Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine

2. Division of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Tohoku University

3. Division of Cell Biology, Department of Pharmaceutical Sciences, School of Pharmacy, International University of Health and Welfare

4. Division of Immunobiology, Department of Pharmaceutical Sciences, School of Pharmacy, International University of Health and Welfare

5. Division of Oral Molecular Regulation, Graduate School of Dentistry, Tohoku University

6. Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference53 articles.

1. 1) Roelofs AJ, Thompson K, Gordon S, Rogers MJ. Molecular mechanisms of action of bisphosphonates: current status. Clin. Cancer Res., 12, 6222s–6230s (2006).

2. 2) Adami S, Zamberlan N. Adverse effects of bisphosphonates. A comparative review. Drug Saf., 14, 158–170 (1996).

3. 3) Ruggiero SL. Bisphosphonate-related osteonecrosis of the jaw (BRONJ): initial discovery and subsequent development. J. Oral Maxillofac. Surg., 67 (Suppl.), 13–18 (2009).

4. 4) Woo SB, Hellstein JW, Kalmar JR. Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. Ann. Intern. Med., 144, 753–761 (2006).

5. 5) Yamaguchi K, Oizumi T, Funayama H, Kawamura H, Sugawara S, Endo Y. Osteonecrosis of the jawbones in 2 osteoporosis patients treated with nitrogen-containing bisphosphonates: osteonecrosis reduction replacing NBP with non-NBP (etidronate) and rationale. J. Oral Maxillofac. Surg., 68, 889–897 (2010).

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