Inhibition of MAPKs Signaling Pathways Prevents Acrolein-Induced Neurotoxicity in HT22 Mouse Hippocampal Cells

Author:

Liu MengTing1,Huang YingJuan1,Qin Jian1,Wang YuanYuan2,Ke Bin1,Yang YuBin1

Affiliation:

1. Department of Traditional Chinese Medicine, the First Affiliated Hospital, Sun Yat-sen University

2. Department of Traditional Chinese Medicine, the Eastern Hospital of the First Affiliated Hospital, Sun Yat-sen University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference34 articles.

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2. 2) Chen Z, Zhong C. Decoding Alzheimer’s disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. Prog. Neurobiol., 108, 21–43 (2013).

3. 3) Moghe A, Ghare S, Lamoreau B, Mohammad M, Barve S, McClain C, Joshi-Barve S. Molecular mechanisms of acrolein toxicity: relevance to human disease. Toxicol. Sci., 143, 242–255 (2015).

4. 4) Chakrabarti S, Sinha M, Thakurta IG, Banerjee P, Chattopadhyay M. Oxidative stress and amyloid beta toxicity in Alzheimer’s disease: intervention in a complex relationship by antioxidants. Curr. Med. Chem., 20, 4648–4664 (2013).

5. 5) Tsou HH, Hsu WC, Fuh JL, Chen SP, Liu TY, Wang HT. Alterations in acrolein metabolism contribute to Alzheimer’s disease. J. Alzheimer’s Dis., 61, 571–580 (2018).

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