Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with <i>in Vitro</i>–<i>in Vivo</i> Extrapolation and Allometric Scaling-Reference-Cited by-同舟云学术

Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with in Vitro–in Vivo Extrapolation and Allometric Scaling

Published:2019-03-01 Issue:3 Volume:42 Page:327-336
ISSN:0918-6158
Container-title:Biological and Pharmaceutical Bulletin
language:en
Short-container-title:Biol. Pharm. Bull.

Author:

Naritomi Yoichi¹,Sanoh Seigo²,Ohta Shigeru²

Affiliation:

1. Analysis & Pharmacokinetics Research Laboratories, Astellas Pharma Inc.

2. Graduate School of Biomedical and Health Sciences, Hiroshima University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

https://www.jstage.jst.go.jp/article/bpb/42/3/42_b18-00754/_pdf

Reference91 articles.

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3. 3) Naritomi Y. Future perspectives of predicting human pharmacokinetics. Drug Metab. Pharmacokinet., 29, 287–288 (2014).

4. 4) Naritomi Y, Nakamori F, Furukawa T, Tabata K. Prediction of hepatic and intestinal glucuronidation using in vitro–in vivo extrapolation. Drug Metab. Pharmacokinet., 30, 21–29 (2015).

5. 5) Zou P, Yu Y, Zheng N, Yang Y, Paholak HJ, Yu LX, Sun D. Applications of human pharmacokinetic prediction in first-in-human dose estimation. AAPS J., 14, 262–281 (2012).

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