The Studies on the Structure-Activity Relationship of Allyl Substituted Oxopyrimidines Searching for the Novel Antagonist or Agonist of Barbiturates to the Sleep Mechanism Based on the Uridine Receptor Theory —Barbituric Acid to Uridine (Part I)1)

Author:

YAMAMOTO Ikuo1

Affiliation:

1. Faculty of Pharmaceutical Sciences, Hokuriku University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology

Reference91 articles.

1. 1) The JPS Award for the Divisional Scientific Contribution in 2002 was given to this review described on the title of “The Biological and Pharmaceutical Studies on the Action Mechanism of Cannabinoids and Uridine Derivatives as CNS Depressant”. However, part of cannabinoids was already appeared in “Pharmacology and Toxicology of Major Constituents of Marijuana-On the Metabolic Activation of Cannabinoids and Its Mechanism,” by Yamamoto I., et al., J. Toxicol. Toxin Rev., 22, 577-589 (2003).

2. 2) Inoue S., Yamamoto I., “Mechanism of Sleep”, Asakura, Tokyo, 1997, pp. 103-122.

3. 3) Inoue S., “Sleep Substances: Their Roles and Evolution. Endogenous Sleep Substances and Sleep Regulation,” eds. by Inoue S., Borbely A. A., Japan Scientific Societies Press, Tokyo/VNU Science Press, Utrecht, 1985, pp. 3-12.

4. 4) Kimura T., Ho I.K., Yamamoto I., Sleep, 24, 251-260 (2001).

5. 5) Sharpless S.K., “Goodman and Gilman's the Pharmacological Basis of Therapeutics, 4th Ed.,” eds. by Goodman L. S., Gilman A., McMillan Publishing Co., Inc., New York, 1970, pp. 98-134.

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