Detection of Residual Solvents in Commercial Supplements Using Headspace (HS)-GC-MS

Author:

Takahashi Mitsuko1,Sugaya Naeko1,Sakurai Hikaru1,Sakurai Katsumi1

Affiliation:

1. Yokohama City Institute of Public Health

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology

Reference40 articles.

1. 1) Ministry of Health, Labour and Welfare, Notification No. 0201003, “Basic concepts related to good manufacture of food supplements formed such as capsules and tablets” and “Guidelines of self-inspection for safety of raw materials in food supplements formed such as capsules and tablets,” February 2005.

2. 2) Ministry of Health, Labour and Welfare, “Japan's Specifications and Standards for Food Additives,” 9th ed., 2018, pp. 1029-1031.

3. 3) Yakuji Kanshi Kenkyukai, “Guidebook of Scope Criteria for Pharmaceutical Products,” 5th ed., Jiho Inc., Tokyo, 2008, pp. 78-104.

4. 4) International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH), “Impurities: Guideline for Residual Solvents Q3C (R3),” July 1997.

5. 5) Ministry of Health, Labour and Welfare, Notification No. 307, “Guideline for residual solvents of pharmaceuticals,” March 1998.

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