In Vitro Assays for the Prediction of Tumorigenic Potential of Non-genotoxic Carcinogens

Author:

Ohmori Kiyomi1

Affiliation:

1. Chemistry Division, Kanagawa Prefectural Institute of Public Health

Publisher

Pharmaceutical Society of Japan

Subject

Health, Toxicology and Mutagenesis,Toxicology

Reference38 articles.

1. 1) Berenblum, I. (1941) The mechanism of carcinogenesis. A study of the significance of cocarcinogenic action and related phenomena. Cancer Res., 1, 807-814.

2. v-ras genes from harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis

3. 3) The ICH Steering Committee (1997) Genotoxicity: A standard battery for genotoxicity testing of pharmaceuticals. ICH Harmonised Tripartite Guideline, pp. 1-6.

4. 4) Combes, R. D. (1997) Detection of non-genotoxic carcinogens: major barriers to replacement of the rodent assay. In Animal Alternatives, Welfare and Ethics (van Zutphen, L. F. M. and Balls, M. eds.), pp. 627-634, Elsevier, Amsterdam, The Netherlands.

5. Tumor promoters inhibit metabolic cooperation in cocultures of epidermal and 3T3 cells

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