Orally Active GPIIb/IIIa Antagonists. Synthesis and Biological Activities of Masked Amidines as Prodrugs of 2-[(3S)-4-[(2S)-2-(4-Amidinobenzoylamino)-3-(4-methoxyphenyl)propanoyl]-3-(2-methoxy-2-oxoethyl)-2-oxopiperazinyl] acetic Acid.-Reference-Cited by-同舟云学术

Orally Active GPIIb/IIIa Antagonists. Synthesis and Biological Activities of Masked Amidines as Prodrugs of 2-[(3S)-4-[(2S)-2-(4-Amidinobenzoylamino)-3-(4-methoxyphenyl)propanoyl]-3-(2-methoxy-2-oxoethyl)-2-oxopiperazinyl] acetic Acid.

Published:2001 Issue:3 Volume:49 Page:268-277
ISSN:0009-2363
Container-title:Chemical and Pharmaceutical Bulletin
language:en
Short-container-title:CHEMICAL & PHARMACEUTICAL BULLETIN

Author:

KITAMURA Shuji¹,FUKUSHI Hideto²,MIYAWAKI Toshio¹,KAWAMURA Masaki³,TERASHITA Zen-ichi³,NAKA Takehiko¹

Affiliation:

1. Medicinal Chemistry Research Laboratories, Takeda Chemical Industries, Ltd.

2. Discovery Research Laboratories V, Takeda Chemical Industries, Ltd.

3. Pharmacology Research Laboratories I, Takeda Chemical Industries, Ltd.

Publisher

Pharmaceutical Society of Japan

Subject

Drug Discovery,General Chemistry,General Medicine

Link

http://www.jstage.jst.go.jp/article/cpb/49/3/49_3_268/_pdf

Reference32 articles.

1. The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets.

2. The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets.

3. Arginyl-glycyl-aspartic acid sequences and fibrinogen binding to platelets

4. The platelet membrane glycoprotein IIb-IIIa complex

5. Echistatin. A potent platelet aggregation inhibitor from the venom of the viper, Echis carinatus.

Cited by 30 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Methyl esters of 2-(N-hydroxycarbamimidoyl)benzoyl-substituted α-amino acids as promising building blocks in peptidomimetic synthesis: a comparative study;Monatshefte für Chemie - Chemical Monthly;2018-10-20

2. Rh(II)-Catalyzed Transannulation of 1,2,4-Oxadiazole Derivatives with 1-Sulfonyl-1,2,3-triazoles: Regioselective Synthesis of 5-Sulfonamidoimidazoles;The Journal of Organic Chemistry;2018-07-30

3. Synthesis and conformational study of novel pyrazine-based pseudopeptides bearing amidoxime, amidoxime ester and 1,2,4-oxadiazole units;Tetrahedron;2016-06

4. One-pot synthesis of (5-alkyl-1,2,4-oxadiazol-3-yl)benzoic acids;Mendeleev Communications;2015-03

5. Synthesis of benzoic acids containing a 1,2,4-oxadiazole ring;Russian Chemical Bulletin;2015-01