Yokukansan, a Traditional Japanese Medicine, Enhances the L-DOPA-Induced Rotational Response in 6-Hydroxydopamine-Lesioned Rats: Possible Inhibition of COMT

Author:

Ishida Yasushi1,Ebihara Kosuke1,Tabuchi Masahiro2,Imamura Sachiko2,Sekiguchi Kyoji2,Mizoguchi Kazushige2,Kase Yoshio2,Koganemaru Go1,Abe Hiroshi13,Ikarashi Yasushi2

Affiliation:

1. Department of Psychiatry, Faculty of Medicine, University of Miyazaki

2. Tsumura Research Laboratories, Kampo Scientific Strategies Division, Tsumura & Co.

3. School of Psychological Science, Health Sciences University of Hokkaido

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference54 articles.

1. 1) Hayashi Y, Ishida Y, Inoue T, Udagawa M, Takeuchi K, Yoshimuta H, Kiue K, Ninomiya Y, Kawano J, Sameshima T, Kawahara T, Goto I, Shudo K, Kurayama S, Nakamura J, Okahara K, Mitsuyama Y. Treatment of behavioral and psychological symptoms of Alzheimer’s-type dementia with Yokukansan in clinical practice. Prog. Neuropsychopharmacol. Biol. Psychiatry, 34, 541–545 (2010).

2. 2) Matsuda Y, Kishi T, Shibayama H, Iwata N. Yokukansan in the treatment of behavioral and psychological symptoms of dementia: a systematic review and meta-analysis of randomized controlled trials. Hum. Psychopharmacol., 28, 80–86 (2013).

3. 3) Okahara K, Ishida Y, Hayashi Y, Inoue T, Tsuruta K, Takeuchi K, Yoshimuta H, Kiue K, Ninomiya Y, Kawano J, Yoshida K, Noda S, Tomita S, Fujimoto M, Hosomi J, Mitsuyama Y. Effects of Yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimer’s disease. Prog. Neuropsychopharmacol. Biol. Psychiatry, 34, 532–536 (2010).

4. 4) Iwasaki K, Maruyama M, Tomita N, Furukawa K, Nemoto M, Fujiwara H, Seki T, Fujii M, Kodama M, Arai H. Effects of the traditional Chinese herbal medicine Yi-Gan San for cholinesterase inhibitor-resistant visual hallucinations and neuropsychiatric symptoms in patients with dementia with Lewy bodies. J. Clin. Psychiatry, 66, 1612–1613 (2005).

5. 5) Iwasaki K, Kosaka K, Mori H, Okitsu R, Furukawa K, Manabe Y, Yoshita M, Kanamori A, Ito N, Wada K, Kitayama M, Horiguchi J, Yamaguchi S, Takayama S, Fukuhara R, Ouma S, Nakano S, Hashimoto M, Kinoshita T. Improvement in delusions and hallucinations in patients with dementia with Lewy bodies upon administration of yokukansan, a traditional Japanese medicine. Psychogeriatrics, 12, 235–241 (2012).

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