Development of a Transnasal Delivery System for Recombinant Human Growth Hormone (rhGH): Effects of the Concentration and Molecular Weight of Poly-L-arginine on the Nasal Absorption of rhGH in Rats
Author:
Affiliation:
1. Faculty of Pharmaceutical Sciences, Josai University
2. Tokai University School of Medicine
3. Research Institute of TTS Technology, Josai University
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/39/3/39_b15-00657/_pdf
Reference24 articles.
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2. 2) Khafagy el-S, Morishita M, Isowa K, Imai J, Takayama K. Effect of cell-penetrating peptides on the nasal absorption of insulin. J. Control. Release, 133, 103–108 (2009).
3. 3) Rawat A, Yang T, Hussain A, Ahsan F. Complexation of a poly-L-arginine with low molecular weight heparin enhances pulmonary absorption of the drug. Pharm. Res., 25, 936–948 (2008).
4. 4) Hartmann K, Ittner J, Müller-Rossberg E, Schönau E, Stephan R, Ullrich KP, Hoppe B, Ramseger R, Brämswig J. Growth hormone treatment adherence in prepubertal and pubertal children with different growth disorders. Horm. Res. Paediatr., 80, 1–5 (2013).
5. 5) Cutfield WS, Derraik JGB, Gunn AJ, Reid K, Delany T, Robinson E, Hofman PL. Non-compliance with growth hormone treatment in children is common and impairs linear growth. PLoS ONE, 6, e16223 (2011).
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