Reduced Food-Effect on Intestinal Absorption of Dronedarone by Self-microemulsifying Drug Delivery System (SMEDDS)

Author:

Han Sang Duk1,Jung Sang Won1,Jang Sun Woo1,Son Miwon1,Kim Byoung Moon1,Kang Myung Joo2

Affiliation:

1. Dong-A Pharmaceutical Co., Ltd.

2. College of Pharmacy, Dankook University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference32 articles.

1. 1) Doggrell SA, Hancox JC. Dronedarone: an amiodarone analogue. Expert Opin. Investig. Drugs, 13, 415–426 (2004).

2. 2) Hohnloser SH, Connolly SJ, Crijns HJ, Page RL, Seiz W, Torp-Petersen C. Rationale and design of ATHENA: A placebo-controlled, double-blind, parallel arm trial to assess the efficacy of dronedarone 400 mg bid for the prevention of cardiovascular hospitalization or death from any cause in patients with atrial fibrillation/atrial flutter. J. Cardiovasc. Electrophysiol., 19, 69–73 (2008).

3. 3) Multaq® FDA Clinical pharmacology and biopharmaceutics reviews, 2009.

4. 4) Abramovici B, Gautier JC, Gromenil JC, Marrier JM. Tablet form for oral administration of amiodarone hydrochloride or dronedarone hydrochloride; antiarrhythmic agents, U.S.7323493 (1998).

5. 5) Gursoy RN, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed. Pharmacother, 58, 173–182 (2004).

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