TLSC702, a Novel Inhibitor of Human Glyoxalase I, Induces Apoptosis in Tumor Cells
Author:
Affiliation:
1. Faculty of Pharmaceutical Sciences, Tokyo University of Science
2. Institute for Theoretical Medicine, Inc.
3. Genome & Drug Research Center, Tokyo University of Science
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/39/5/39_b15-00710/_pdf
Reference23 articles.
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2. 2) Kang Y, Edwards LG, Thornalley PJ. Effect of methylglyoxal on human leukaemia 60 cell growth: modification of DNA G1 growth arrest and induction of apoptosis. Leuk. Res., 20, 397–405 (1996).
3. 3) Ranganathan S, Tew KD. Analysis of glyoxalase-I from normal and tumor tissue. Biochim. Biophys. Acta, 1182, 311–316 (1993).
4. 4) Wang Y, Kuramitsu Y, Ueno T, Suzuki N, Yoshino S, Iizuka N, Akada J, Kitagawa T, Oka M, Nakamura K. Glyoxalase I (GLO1) is up-regulated in pancreatic cancerous tissues compared with related non-cancerous tissues. Anticancer Res., 32, 3219–3222 (2012).
5. 5) Bair WB 3rd, Cabello CM, Uchida K, Bause AS, Wondrak GT. GLO1 overexpression in human malignant melanoma. Melanoma Res., 20, 85–96 (2010).
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