Torsadogenic Potential of HCN Channel Blocker Ivabradine Assessed in the Rabbit Proarrhythmia Model
Author:
Affiliation:
1. Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/44/11/44_b21-00605/_pdf
Reference21 articles.
1. 1) Ide T, Ohtani K, Higo T, Tanaka M, Kawasaki Y, Tsutsui H. Ivabradine for the treatment of cardiovascular diseases. Circ. J., 83, 252–260 (2019).
2. 2) Koncz I, Szél T, Bitay M, Cerbai E, Jaeger K, Fülöp F, Jost N, Virág L, Orvos P, Tálosi L, Kristóf A, Baczkó I, Papp JG, Varró A. Electrophysiological effects of ivabradine in dog and human cardiac preparations: potential antiarrhythmic actions. Eur. J. Pharmacol., 668, 419–426 (2011).
3. 3) Mackiewicz U, Gerges JY, Chu S, Duda M, Dobrzynski H, Lewartowski B, Mączewski M. Ivabradine protects against ventricular arrhythmias in acute myocardial infarction in the rat. J. Cell. Physiol., 229, 813–823 (2014).
4. 4) Vaillant F, Timour Q, Descotes J, Manati W, Belhani D, Bui-Xuan B, Tabib A, Bricca G, Chevalier P. Ivabradine induces an increase in ventricular fibrillation threshold during acute myocardial ischemia: an experimental study. J. Cardiovasc. Pharmacol., 52, 548–554 (2008).
5. 5) Jang JH, Kwon SW, Lee MJ, Ko KY, Park JH, Yoon GS, Choi SH, Beak YS, Park SD, Shin SH, Woo SI, Kim DH, Kwan J. Ivabradine-induced torsade de pointes in patients with heart failure reduced ejection fraction. Int. Heart J., 61, 1044–1048 (2020).
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