Increasing Tumor Extracellular pH by an Oral Alkalinizing Agent Improves Antitumor Responses of Anti-PD-1 Antibody: Implication of Relationships between Serum Bicarbonate Concentrations, Urinary pH, and Therapeutic Outcomes-Reference-Cited by-同舟云学术

Increasing Tumor Extracellular pH by an Oral Alkalinizing Agent Improves Antitumor Responses of Anti-PD-1 Antibody: Implication of Relationships between Serum Bicarbonate Concentrations, Urinary pH, and Therapeutic Outcomes

Published:2021-06-01 Issue:6 Volume:44 Page:844-852
ISSN:0918-6158
Container-title:Biological and Pharmaceutical Bulletin
language:en
Short-container-title:Biol. Pharm. Bull.

Author:

Ando Hidenori¹,Emam Sherif E.¹²,Kawaguchi Yoshino¹,Shimizu Taro¹,Ishima Yu¹,Eshima Kiyoshi³,Ishida Tatsuhiro¹

Affiliation:

1. Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University

2. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University

3. Delta-Fly Pharma Inc.

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

https://www.jstage.jst.go.jp/article/bpb/44/6/44_b21-00076/_pdf

Reference45 articles.

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3. 3) Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res., 49, 6449–6465 (1989).

4. 4) Madshus IH. Regulation of intracellular pH in eukaryotic cells. Biochem. J., 250, 1–8 (1988).

5. 5) Warburg O. On the origin of cancer cells. Science, 123, 309–314 (1956).

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