Involvement of the Peripheral μ-Opioid Receptor in Tramadol-Induced Constipation in Rodents

Author:

Yasufuku Kana1,Koike Katsumi1,Kobayashi Mika2,Chiba Hiroki2,Kitaura Motoji3,Takenouchi Shino4,Hasegawa Minoru1,Morioka Yasuhide5,Mishima Hirokazu5,Suzuki Tsutomu6,Fujita Masahide1

Affiliation:

1. Laboratory for Drug Discovery and Disease Research, Shionogi & Co., Ltd.

2. Research Area for Pharmacological Evaluation, Shionogi TechnoAdvance Research Co., Ltd.

3. General Administration Division, Shionogi Administration Service Co., Ltd.

4. Transgenic and Breeding Technology, Shionogi TechnoAdvance Research Co., Ltd.

5. Medical Affairs Department, Shionogi & Co., Ltd.

6. Department of Pharmacology, School of Pharmacy, Shonan University of Medical Sciences

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference35 articles.

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2. 2) Benyamin R, Trescot AM, Datta S, Buenaventura R, Adlaka R, Sehgal N, Glaser SE, Vallejo R. Opioid complications and side effects. Pain Physician, 11 (Suppl.), S105–S120 (2008).

3. 3) Raffa RB, Friderichs E, Reimann W, Shank RP, Codd EE, Vaught JL. Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an ‘atypical’ opioid analgesic. J. Pharmacol. Exp. Ther., 260, 275–285 (1992).

4. 4) Desmeules JA, Piguet V, Collart L, Dayer P. Contribution of monoaminergic modulation to the analgesic effect of tramadol. Br. J. Clin. Pharmacol., 41, 7–12 (1996).

5. 5) Gillen C, Haurand M, Kobelt DJ, Wnendt S. Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor. Naunyn Schmiedebergs Arch. Pharmacol., 362, 116–121 (2000).

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