Transduction Properties of an Adenovirus Vector Containing Sequences Complementary to a Liver-Specific microRNA, miR-122a, in the 3′-Untranslated Region of the E4 Gene in Human Hepatocytes from Chimeric Mice with Humanized Liver-Reference-Cited by-同舟云学术

Transduction Properties of an Adenovirus Vector Containing Sequences Complementary to a Liver-Specific microRNA, miR-122a, in the 3′-Untranslated Region of the E4 Gene in Human Hepatocytes from Chimeric Mice with Humanized Liver

Published:2021-10-01 Issue:10 Volume:44 Page:1506-1513
ISSN:0918-6158
Container-title:Biological and Pharmaceutical Bulletin
language:en
Short-container-title:Biol. Pharm. Bull.

Author:

Sakurai Fuminori¹,Tsukamoto Tomohito¹,Ono Ryosuke¹,Nishimae Fumitaka¹,Shiota Aoi¹,Iizuka Shunsuke¹,Shimizu Kahori¹,Sakai Eiko¹,Ishida Yuji²,Tateno Chise²,Chayama Kazuaki³,Mizuguchi Hiroyuki⁴

Affiliation:

1. Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University

2. PhoenixBio Co., Ltd.

3. RIKEN Center for Integrative Medical Sciences

4. Global Center for Medical Engineering and Informatics, Osaka University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

https://www.jstage.jst.go.jp/article/bpb/44/10/44_b21-00394/_pdf

Reference37 articles.

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2. 2) Yang Y, Nunes FA, Berencsi K, Furth EE, Gonczol E, Wilson JM. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. U.S.A., 91, 4407–4411 (1994).

3. 3) Engelhardt JF, Ye X, Doranz B, Wilson JM. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. U.S.A., 91, 6196–6200 (1994).

4. 4) Shimizu K, Sakurai F, Tomita K, Nagamoto Y, Nakamura S, Katayama K, Tachibana M, Kawabata K, Mizuguchi H. Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome. Mol. Ther. Methods Clin. Dev., 1, 14035 (2014).

5. 5) Gallo-Penn AM, Shirley PS, Andrews JL, Tinlin S, Webster S, Cameron C, Hough C, Notley C, Lillicrap D, Kaleko M, Connelly S. Systemic delivery of an adenoviral vector encoding canine factor VIII results in short-term phenotypic correction, inhibitor development, and biphasic liver toxicity in hemophilia A dogs. Blood, 97, 107–113 (2001).

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