Evaluation of New Pregnane Derivatives as 5.ALPHA.-Reductase Inhibitor.

Author:

CABEZA Marisa1,HEUZE Ivonne1,BRATOEFF Eugene2,RAMIREZ Elena2,MARTINEZ Rosa2

Affiliation:

1. Departments of Biological Systems, Agricultural and Animal Production of the Metropolitan University of Mexico Campus Xochimilco

2. Faculty of Chemistry, National University of Mexico

Publisher

Pharmaceutical Society of Japan

Subject

Drug Discovery,General Chemistry,General Medicine

Reference19 articles.

1. The Conversion of Testosterone to 5α-Androstan-17β-ol-3-one by Rat Prostate in Vivo and in Vitro

2. Activity of 17β-(N-Alkyl/arylformamido) and 17β-[(N-Alkyl/aryl) alkyl/arylamido]-4-methyl-4-aza-5α-androstan-3-ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear11The research has been supported by Endorecherche that is seeking patent protection for the new compounds. F. Labrie is President of Endorecherche.

3. 3) Raynaud J.P., Azadian-Boulanger B., Bonne C., Perronnet J., Sakis E., Present trends In: Antiandrogen Research in Androgens and Antiandrogens, Martini L, Motta M. Raven Press: New York, 1977, pp. 309-311.

4. 4) Brooks J.R., Harris G.S., Sandler M., Smitter H.J. (eds.) “Design of Enzyme Inhibitors as Drugs,” Vol. 2, Oxford University Press, Oxford, 1994, pp. 495-498.

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