Effect of Severe Renal Dysfunction on the Plasma Levels of DNA-Reactive Platinum after Oxaliplatin Administration

Author:

Nakagawa Shunsaku1,Shimazaki Aimi1,Funakoshi Taro2,Yonezawa Atsushi1,Kataoka Shigeki2,Horimatsu Takahiro2,Hira Daiki1,Itohara Kotaro1,Imai Satoshi1,Nakagawa Takayuki1,Matsubara Takeshi3,Yanagita Motoko3,Muto Manabu2,Matsubara Kazuo4,Terada Tomohiro1

Affiliation:

1. Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital

2. Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University

3. Department of Nephrology, Graduate School of Medicine, Kyoto University

4. Department of Pharmacy, Wakayama Medical University Hospital

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference28 articles.

1. 1) Nikanjam M, Stewart CF, Takimoto CH, Synold TW, Beaty O, Fouladi M, Capparelli EV. Population pharmacokinetic analysis of oxaliplatin in adults and children identifies important covariates for dosing. Cancer Chemother. Pharmacol., 75, 495–503 (2015).

2. 2) Massari C, Brienza S, Rotarski M, Gastiaburu J, Misset JL, Cupissol D, Alafaci E, Dutertre-Catella H, Bastian G. Pharmacokinetics of oxaliplatin in patients with normal versus impaired renal function. Cancer Chemother. Pharmacol., 45, 157–164 (2000).

3. 3) Takimoto CH, Remick SC, Sharma S, Mani S, Ramanathan RK, Doroshow J, Hamilton A, Mulkerin D, Graham M, Lockwood GF, Ivy P, Egorin M, Schuler B, Greenslade D, Goetz A, Knight R, Thomas R, Monahan BP, Dahut W, Grem JL. Dose-escalating and pharmacological study of oxaliplatin in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study. J. Clin. Oncol., 21, 2664–2672 (2003).

4. 4) Takimoto CH, Graham MA, Lockwood G, Ng CM, Goetz A, Greenslade D, Remick SC, Sharma S, Mani S, Ramanathan RK, Synold TW, Doroshow JH, Hamilton A, Mulkerin DL, Ivy P, Egorin MJ, Grem JL. Oxaliplatin pharmacokinetics and pharmacodynamics in adult cancer patients with impaired renal function. Clin. Cancer Res., 13, 4832–4839 (2007).

5. 5) Watanabe D, Fujii H, Yamada Y, Iihara H, Ishihara T, Matsuhashi N, Takahashi T, Yoshida K, Suzuki A. Relationship between renal function and the incidence of adverse events in patients with colorectal cancer receiving oxaliplatin. Anticancer Res., 40, 299–304 (2020).

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