Blocking CXC Motif Chemokine Ligand 2 Ameliorates Diabetic Peripheral Neuropathy <i>via</i> Inhibiting Apoptosis and NLRP3 Inflammasome Activation
Author:
Affiliation:
1. Department of Endocrinology and Metabolism, The First Affiliated Hospital of Zhengzhou University
2. Department of Neurology, The Third Affiliated Hospital of Xinxiang Medical University
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/46/5/46_b22-00680/_pdf
Reference57 articles.
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2. 2) Bönhof GJ, Herder C, Strom A, Papanas N, Roden M, Ziegler D. Emerging biomarkers, tools, and treatments for diabetic rolyneuropathy. Endocr. Rev., 40, 153–192 (2019).
3. 3) Zhang X, Zhao S, Yuan Q, Zhu L, Li F, Wang H, Kong D, Hao J. TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression. Cell Death Dis., 12, 642 (2021).
4. 4) Calcutt NA, Smith DR, Frizzi K, Sabbir MG, Chowdhury SKR, Mixcoatl-Zecuatl T, Saleh A, Muttalib N, Van der Ploeg R, Ochoa J, Gopaul A, Tessler L, Wess J, Jolivalt CG, Fernyhough P. Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy. J. Clin. Invest., 127, 608–622 (2017).
5. 5) Baum P, Toyka KV, Blüher M, Kosacka J, Nowicki M. Inflammatory mechanisms in the pathophysiology of diabetic peripheral neuropathy (DN)—new aspects. Int. J. Mol. Sci., 22, 10835 (2021).
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