Effect of Replicative Senescence on the Expression and Function of Transporters in Human Proximal Renal Tubular Epithelial Cells

Author:

Sanagawa Akimasa1,Hotta Yuji2,Sezaki Rara2,Tomita Natsumi2,Kataoka Tomoya3,Furukawa-Hibi Yoko2,Kimura Kazunori1

Affiliation:

1. Department of Pharmacy, Nagoya City University Hospital

2. Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University

3. Department of Clinical Pharmaceutics, Graduate School of Medical Sciences, Nagoya City University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference34 articles.

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2. 2) Vinken M. 3Rs toxicity testing and disease modeling projects in the European Horizon 2020 research and innovation program. EXCLI J., 19, 775–784 (2020).

3. 3) Faria J, Ahmed S, Gerritsen KGF, Mihaila SM, Masereeuw R. Kidney-based in vitro models for drug-induced toxicity testing. Arch. Toxicol., 93, 3397–3418 (2019).

4. 4) Chen WY, Evangelista EA, Yang J, Kelly EJ, Yeung CK. Kidney organoid and microphysiological kidney chip models to accelerate drug development and reduce animal testing. Front. Pharmacol., 12, 695920 (2021).

5. 5) Ghallab A. In vitro test systems and their limitations. EXCLI J., 12, 1024–1026 (2013).

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