3-Nitropropionic Acid Enhances Ferroptotic Cell Death <i>via</i> NOX2-Mediated ROS Generation in STHdhQ111 Striatal Cells Carrying Mutant Huntingtin
Author:
Affiliation:
1. Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/46/2/46_b22-00529/_pdf
Reference19 articles.
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2. 2) Wexler NS, Lorimer J, Porter J, et al. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington’s disease age of onset. Proc. Natl. Acad. Sci. U.S.A., 101, 3498–3503 (2004).
3. 3) Gusella JF, MacDonald ME. Huntington’s disease: the case for genetic modifiers. Genome Med., 1, 80 (2009).
4. 4) Kwon D. Failure of genetic therapies for Huntington’s devastates community. Nature, 593, 180 (2021).
5. 5) Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, Lawton M, Trottier Y, Lehrach H, Davies SW, Bates GP. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell, 87, 493–506 (1996).
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