Protective Effect of Fuzi Lizhong Decoction against Non-alcoholic Fatty Liver Disease via Anti-inflammatory Response through Regulating p53 and PPARG Signaling

Author:

Yang Jiayao1,Ma Wei1,Mei Qunchao1,Song Juefei2,Shu Lei1,Zhang Shu1,Li Chenyu3,An Liu3,Du Nianlong1,Shi Zhaohong1

Affiliation:

1. Department of Gastroenterology, Wuhan Hospital of Traditional Chinese and Western Medicine

2. Department of Medical Services, Hongan County People’s Hospital

3. Department of Traditional Chinese Medicine, Hubei University of Traditional Chinese Medicine

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference35 articles.

1. 1) Dowman JK, Tomlinson JW, Newsome PN. Pathogenesis of non-alcoholic fatty liver disease. QJM, 103, 71–83 (2010).

2. 2) Byrne CD. Fatty liver: role of inflammation and fatty acid nutrition. Prostaglandins Leukot. Essent. Fatty Acids, 82, 265–271 (2010).

3. 3) LaBrecque DR, Abbas Z, Anania F, Ferenci P, Khan AG, Goh KL, Hamid SS, Isakov V, Lizarzabal M, Penaranda MM, Ramos JF, Sarin S, Stimac D, Thomson AB, Umar M, Krabshuis J, LeMair A. World Gastroenterology Organisation global guidelines: Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. J. Clin. Gastroenterol., 48, 467–473 (2014).

4. 4) Baffy G. Kupffer cells in non-alcoholic fatty liver disease: the emerging view. J. Hepatol., 51, 212–223 (2009).

5. 5) Wen J, Zou W, Wang R, Liu H, Yang Y, Li H, Wei S, Li R, Cai H, Wang J, Zhao Y. Cardioprotective effects of Aconiti Lateralis Radix Praeparata combined with Zingiberis Rhizoma on doxorubicin-induced chronic heart failure in rats and potential mechanisms. J. Ethnopharmacol., 238, 111880 (2019).

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