Screening of Promising Chemotherapeutic Candidates from Plants against Human Adult T-Cell Leukemia/Lymphoma (VI): Cardenolides from Asclepias curassavica

Author:

Nakano Daisuke1,Ishitsuka Kenji2,Takashima Maya1,Arima Rie1,Satou Aya1,Tsuchihashi Ryota1,Okawa Masafumi1,Tamura Kazuo3,Kinjo Junei1

Affiliation:

1. Faculty of Pharmaceutical Sciences, Fukuoka University

2. Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University

3. Department of Internal Medicine, Division of Medical Oncology, Hematology and Infectious Disease, Fukuoka University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference21 articles.

1. 1) Ishitsuka K, Tamura K. Treatment of adult T-cell leukemia/lymphoma: past, present, and future. Eur. J. Haematol., 80, 185–196 (2008).

2. 2) Miyoshi I, Kubonishi I, Sumida M, Hiraki S, Tsubota T, Kimura I, Miyamoto K, Sato J. A novel T-cell line derived from adult T-cell leukemia. Gann, 71, 155–156 (1980).

3. 3) Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y, Nagata K, Hinuma Y. Type C virus particles in a cord T-cell line derived by cocultivating normal human cord leukocytes and human leukaemic T cells. Nature, 294, 770–771 (1981).

4. 4) Nakano D, Ishitsuka K, Hatsuse T, Tsuchihashi R, Okawa M, Okabe H, Tamura K, Kinjo J. Screening of promising chemotherapeutic candidates against human adult T-cell leukemia/lymphoma from plants: active principles from Physalis pruinosa and structure–activity relationships with withanolides. J. Nat. Med., 65, 559–567 (2011).

5. 5) Nakano D, Ishitsuka K, Katsuya H, Kunami N, Nogami R, Yoshimura Y, Matsuda M, Kamikawa M, Tsuchihashi R, Okawa M, Ikeda T, Nohara T, Tamura K, Kinjo J. Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (II): apoptosis of antiproliferactive principle (24,25-dihydrowithanolide D) against ATL cell lines and structure–activity relationships with withanolides isolated from solanaceous plants. J. Nat. Med., 67, 415–420 (2013).

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