Effects of Palonosetron on Nausea and Vomiting Induced by Multiple-Day Chemotherapy: A Retrospective Study

Author:

Hamano Hirofumi1,Mitsuhashi Chisato2,Suzuki Yoshiko3,Zamami Yoshito12,Tsujinaka Kaito2,Okada Naoto2,Niimura Takahiro1,Hayama Tatsuya4,Imai Toru4,Ishida Shunsuke2,Sakamoto Kumiko2,Goda Mitsuhiro2,Takechi Kenshi5,Yagi Kenta6,Chuma Masayuki6,Horinouchi Yuya7,Shinomiya Kazuaki7,Ikeda Yasumasa8,Kirino Yasushi2,Nakamura Toshimi2,Yanagawa Hiroaki6,Hamada Yasuhiro3,Ishizawa Keisuke12

Affiliation:

1. Department of Clinical Pharmacology and Therapeutics, Institute of Biomedical Sciences, Tokushima University Graduate School

2. Department of Pharmacy, Tokushima University Hospital

3. Department of Therapeutic Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School

4. Department of Pharmacy, Nihon University Itabashi Hospital

5. Department of Drug Information Analysis, College of Pharmaceutical Sciences, Matsuyama University

6. Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital

7. Department of Pharmaceutical Care and Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Tokushima Bunri Universityy

8. Department of Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference36 articles.

1. 1) Popovic M, Warr DG, Deangelis C, Tsao M, Chan KK, Poon M, Yip C, Pulenzas N, Lam H, Zhang L, Chow E. Efficacy and safety of palonosetron for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV): a systematic review and meta-analysis of randomized controlled trials. Support. Care Cancer, 22, 1685–1697 (2014).

2. 2) Browning KN. Role of central vagal 5-HT3 receptors in gastrointestinal physiology and pathophysiology. Front. Neurosci, 9, 413 (2015).

3. 3) Roila F, Tonato M, Cognetti F, Cortesi E, Favalli G, Marangolo M, Amadori D, Bella MA, Gramazio V, Donati D. Prevention of cisplatin-induced emesis: a double-blind multicenter randomized crossover study comparing ondansetron and ondansetron plus dexamethasone. J. Clin. Oncol., 9, 675–678 (1991).

4. 4) Italian Group for Antiemetic Research. Dexamethasone, granisetron, or both for the prevention of nausea and vomiting during chemotherapy for cancer. N. Engl. J. Med., 332, 1–5 (1995).

5. 5) Stoltz R, Cyong JC, Shah A, Parisi S. Pharmacokinetic and safety evaluation of palonosetron, a 5-hydroxytryptamine-3 receptor antagonist, in U.S. and Japanese healthy subjects. J. Clin. Pharmacol., 44, 520–531 (2004).

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