Evaluation of Agonistic Activity of Fluorinated and Nonfluorinated Fentanyl Analogs on μ-Opioid Receptor Using a Cell-Based Assay System

Author:

Kanamori Tatsuyuki1,Okada Yuki1,Segawa Hiroki1,Yamamuro Tadashi1,Kuwayama Kenji1,Tsujikawa Kenji1,Iwata Yuko Togawa1

Affiliation:

1. National Research Institute of Police Science

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference10 articles.

1. 1) United Nations Office on Drugs and Crime. “World drug report 2019; 3 depressants.”: ‹https://wdr.unodc.org/wdr2019/prelaunch/WDR19_Booklet_3_DEPRESSANTS.pdf›, accessed 24 September, 2020.

2. 2) United Nations Office on Drugs and Crime. “Fentanyl and its analogues—50 years on. Global Smart Update.”: ‹http://www.unodc.org/documents/scientific/Global_SMART_Update_17_web.pdf›, accessed 24 September, 2020.

3. 3) Zhang R, Xie X. Tools for GPCR drug discovery. Acta Pharmacol. Sin., 33, 372–384 (2012).

4. 4) Siegfried. “Synthesis of fentanyl.”: ‹https://erowid.org/archive/rhodium/chemistry/fentanyl.html›, accessed 24 September, 2020.

5. 5) Golla R, Seethala R. A homogeneous enzyme fragment complementation cyclic AMP screen for GPCR agonists. J. Biomol. Screen., 7, 515–525 (2002).

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