Different Renal Chronotoxicity of Bromobenzene and Its Intermediate Metabolites in Mice

Author:

Yoshioka Hiroki12,Tominaga Sarah1,Nishikawa Mai1,Shinohara Yasuro1,Nakao Makoto1,Yoshikawa Masae1,Maeda Tohru1,Miura Nobuhiko3

Affiliation:

1. College of Pharmacy, Kinjo Gakuin University

2. Center for Craniofacial Research, The University of Texas Health Science Center at Houston, School of Dentistry

3. Department of Health Science, Yokohoma University of Pharmacy

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference14 articles.

1. 1) Lau SS, Monks TJ. The contribution of bromobenzene to our current understanding of chemically-induced toxicities. Life Sci., 42, 1259–1269 (1988).

2. 2) Zhao H, Cheng N, He L, Peng G, Liu Q, Ma T, Cao W. Hepatoprotective Effects of the Honey of apis cerana fabricius on bromobenzene-induced liver damage in mice. J. Food Sci., 83, 509–516 (2018).

3. 3) Vedi M, Sabina EP. Assessment of hepatoprotective and nephroprotective potential of withaferin A on bromobenzene-induced injury in Swiss albino mice: possible involvement of mitochondrial dysfunction and inflammation. Cell Biol. Toxicol., 32, 373–390 (2016).

4. 4) Dankovic DA, Billings RE. The role of 4-bromophenol and 4-bromocatechol in bromobenzene covalent binding and toxicity in isolated rat hepatocytes. Toxicol. Appl. Pharmacol., 79, 323–331 (1985).

5. 5) Lau SS, Monks TJ, Gillette JR. Identification of 2-bromohydroquinone as a metabolite of bromobenzene and o-bromophenol: implications for bromobenzene-induced nephrotoxicity. J. Pharmacol. Exp. Ther., 230, 360–366 (1984).

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