Vitamin K2 Suppresses Proliferation and Inflammatory Cytokine Production in Mitogen-Activated Lymphocytes of Atopic Dermatitis Patients through the Inhibition of Mitogen-Activated Protein Kinases

Author:

Zhang Meiyu12,Miura Taro3,Suzuki Shunsuke3,Chiyotanda Masako4,Tanaka Sachiko1,Sugiyama Kentaro1,Kawashima Hisashi4,Hirano Toshihiko1

Affiliation:

1. Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

2. Experimental Research Center, China Academy of Chinese Medical Sciences

3. Department of Pediatrics, Tokyo Medical University Hachioji Medical Center

4. Department of Pediatrics and Adolescent Medicine, Tokyo Medical University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference40 articles.

1. 1) Xu F, Yan S, Li F, Cai M, Chai W, Wu M, Fu C, Zhao Z, Kan H, Kang K, Xu J. Prevalence of childhood atopic dermatitis: an urban and rural community-based study in Shanghai, China. PLOS ONE, 7, e36174 (2012).

2. 2) Rydzynski K, Palczynski C. Occupational allergy as a challenge to developing countries. Toxicology, 198, 75–82 (2004).

3. 3) Spergel JM. Epidemiology of atopic dermatitis and atopic march in children. Immunol. Allergy Clin. North Am., 30, 269–280 (2010).

4. 4) Kim JE, Kim JS, Cho DH, Park HJ. Molecular mechanisms of cutaneous inflammatory disorder: atopic dermatitis. Int. J. Mol. Sci., 17, 1234 (2016).

5. 5) Avena-Woods C. Overview of atopic dermatitis. Am. J. Manag. Care, 23, S115–S123 (2017).

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