Synergistic Antinociceptive Activity of Tramadol/Acetaminophen Combination Mediated by μ-Opioid Receptors

Author:

Yoshizawa Kazumi1,Arai Narumaki1,Suzuki Yukina1,Fujita Ayumi1,Takahashi Yukino1,Kawano Yayoi2,Hanawa Takehisa2

Affiliation:

1. Laboratory of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science

2. Laboratory of Preformulation Study, Faculty of Pharmaceutical Sciences, Tokyo University of Science

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference26 articles.

1. 1) Leppert W. Tramadol as an analgesic for mild to moderate cancer pain. Pharmacol. Rep., 61, 978–992 (2009).

2. 2) Leppert W. CYP2D6 in the metabolism of opioids for mild to moderate pain. Pharmacology, 87, 274–285 (2011).

3. 3) Gong L, Stamer UM, Tzvetkov MV, Altman RB, Klein TE. PharmGKB summary: tramadol pathway. Pharmacogenet. Genomics, 24, 374–380 (2014).

4. 4) Edwards JE, McQuay HJ, Moore RA. Combination analgesic efficacy: individual patient data meta-analysis of single-dose oral tramadol plus acetaminophen in acute postoperative pain. J. Pain Symptom Manage., 23, 121–130 (2002).

5. 5) Mu A, Weinberg E, Moulin DE, Clarke H. Pharmacologic management of chronic neuropathic pain: Review of the Canadian Pain Society consensus statement. Can. Fam. Physician, 63, 844–852 (2017).

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