The Effect of Antihistamines on Seizures Induced by Increasing-Current Electroshocks: Ketotifen, but Not Olopatadine, Promotes the Seizures in Infant Rats
Author:
Affiliation:
1. Pharmacological Research Laboratories, Research Division, Kyowa Hakko Kirin Co., Ltd.
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/35/5/35_5_693/_pdf
Reference24 articles.
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3. 3) Yokoyama H, Iinuma K, Yanai K, Watanabe T, Sakurai E, Onodera K. Proconvulsant effect of ketotifen, a histamine H1 antagonist, confirmed by the use of D-chlorpheniramine with monitoring electroencephalography. Methods Find. Exp. Clin. Pharmacol., 15, 183–188 (1993).
4. 4) Yasuhara A, Ochi A, Harada Y, Kobayashi Y. Infantile spasms associated with a histamine H1 antagonist. Neuropediatrics, 29, 320–321 (1998).
5. 6) Yokoyama H, Onodera K, Iinuma K, Watanabe T. Proconvulsive effects of histamine H1-antagonists on electrically-induced seizure in developing mice. Psychopharmacology (Berl.), 112, 199–203 (1993).
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