Acyl-glucuronide as a Possible Cause of Trovafloxacin-Induced Liver Toxicity: Induction of Chemokine (C-X-C Motif) Ligand 2 by Trovafloxacin Acyl-glucuronide

Author:

Mitsugi Ryo1,Sumida Kyohei1,Fujie Yoshiko1,Tukey Robert H.2,Itoh Tomoo1,Fujiwara Ryoichi1

Affiliation:

1. Department of Pharmaceutics, School of Pharmacy, Kitasato University

2. Laboratory of Environmental Toxicology, Departments of Chemistry & Biochemistry and Pharmacology, University of California at San Diego

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference41 articles.

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2. 2) Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro SI, Iyanagi T, Miners JO, Owens IS, Nebert DW. Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet. Genomics, 15, 677–685 (2005).

3. 3) Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS. A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP–glucuronosyltransferase isozymes with identical carboxyl termini. J. Biol. Chem., 267, 3257–3261 (1992).

4. 4) Tukey RH, Strassburg CP. Human UDP–glucuronosyltransferases: metabolism, expression, and disease. Annu. Rev. Pharmacol. Toxicol., 40, 581–616 (2000).

5. 5) Fujiwara R, Maruo Y, Chen S, Tukey RH. Role of extrahepatic UDP–glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol. Appl. Pharmacol., 289, 124–132 (2015).

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