Underlying Mechanisms and Therapeutic Strategies for Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ)

Author:

Endo Yasuo1,Kumamoto Hiroyuki2,Nakamura Masanori3,Sugawara Shunji4,Takano-Yamamoto Teruko5,Sasaki Keiichi6,Takahashi Tetsu1

Affiliation:

1. Division of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Tohoku University

2. Division of Oral Pathology, Graduate School of Dentistry, Tohoku University

3. Department of Oral Anatomy and Developmental Biology, School of Dentistry, Showa University

4. Division of Oral Molecular Regulation, Graduate School of Dentistry, Tohoku University

5. Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University

6. Division of Advanced Prosthetic Dentistry, Graduate School of Dentistry, Tohoku University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference103 articles.

1. 1) Fleisch H. Diphosphonates: history and mechanisms of actions. Metab. Bone Dis. Relat. Res., 3, 279–287 (1981).

2. 2) Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J. Oral Maxillofac. Surg., 61, 1115–1117 (2003).

3. 3) Migliorati CA. Bisphosphonates and oral cavity avascular bone necrosis. J. Clin. Oncol., 21, 4253–4254 (2003).

4. 4) Fliefel R, Tröltzsch M, Kühnisch J, Ehrenfeld M, Otto S. Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review. Int. J. Oral Maxillofac. Surg., 44, 568–585 (2015).

5. 5) Geddes AD, D’Souza SM, Ebetino FH, Kenneth JI. Bisphosphonates: structure–activity relationships and therapeutic implications. Bone and Mineral Research (Heershe NM, Kanis JK ed.) Vol. 8, Elsevier Science BV, Amsterdam, Holland, pp. 265–306 (1994).

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