Serotonergic System Does Not Contribute to the Hypothermic Action of Acetaminophen

Author:

Fukushima Akihiro1,Sekiguchi Wakana1,Mamada Kizuku1,Tohma Yumi1,Ono Hideki1

Affiliation:

1. Laboratory of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, Musashino University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference37 articles.

1. 1) Courad JP, Besse D, Delchambre C, Hanoun N, Hamon M, Eschalier A, Caussade F, Cloarec A. Acetaminophen distribution in the rat central nervous system. Life Sci., 69, 1455–1464 (2001).

2. 2) Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A. Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol. Br. J. Clin. Pharmacol., 34, 79–81 (1992).

3. 3) Davison C, Guy JL, Levitt M, Smith PK. The distribution of certain non-narcotic analgetic agents in the CNS of several species. J. Pharmacol. Exp. Ther., 134, 176–183 (1961).

4. 4) Massey TE, Walker RM, McElligott TF, Racz WJ. Acetaminophen-induced hypothermia in mice: evidence for a central action of the parent compound. Toxicology, 25, 187–200 (1982).

5. 5) Pelissier T, Alloui A, Caussade F, Dubray C, Cloarec A, Lavarenne J, Eschalier A. Paracetamol exerts a spinal antinociceptive effect involving an indirect interaction with 5-hydroxytryptamine3 receptors: in vivo and in vitro evidence. J. Pharmacol. Exp. Ther., 278, 8–14 (1996).

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