Chronic Rapamycin Treatment Improved Metabolic Phenotype but Inhibited Adipose Tissue Browning in High-Fat Diet-Fed C57BL/6J Mice-Reference-Cited by-同舟云学术

Chronic Rapamycin Treatment Improved Metabolic Phenotype but Inhibited Adipose Tissue Browning in High-Fat Diet-Fed C57BL/6J Mice

Published:2017 Issue:9 Volume:40 Page:1352-1360
ISSN:0918-6158
Container-title:Biological & Pharmaceutical Bulletin
language:en
Short-container-title:Biol. Pharm. Bull.

Author:

Wang Yan¹,He Zhi²,Li Xianhui³

Affiliation:

1. Pharmacy Department, The First People’s Hospital of Foshan

2. Medical School of China Three Gorges University

3. Institute of Medicine, College of Medicine, Jishou University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

https://www.jstage.jst.go.jp/article/bpb/40/9/40_b16-00946/_pdf

Reference19 articles.

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3. 3) Ray PD, Maclellan RA, He J, Liu Z, Wu J. Downregulation of RelA (p65) by rapamycin inhibits murine adipocyte differentiation and reduces fat mass of C57BL/6J mice despite high fat diet. ISRN. Obes., 2014, 540582 (2014).

4. 4) Wang Y, He Z, Li X, Chen W, Lu J, Chen X, Cao L. Chronic rapamycin treatment exacerbates metabolism and does not down-regulate mTORC2/Akt signaling in diabetic mice induced by high-fat diet and streptozotocin. Pharmazie, 70, 604–609 (2015).

5. 5) Houde VP, Brûlé S, Festuccia WT, Blanchard PG, Bellmann K, Deshaies Y, Marette A. Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes, 59, 1338–1348 (2010).

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