Synthesis of New N1-Substituted-5-aryl-3-(3,4,5-trimethoxyphenyl)-2-pyrazoline Derivatives as Antitumor Agents Targeting the Colchicine Site on Tubulin
Author:
Affiliation:
1. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University
2. Pharmacology & Toxicology Department, Faculty of Pharmacy, Suez Canal University
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/39/10/39_b16-00277/_pdf
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3. 3) Luo Y, Qiu K-M, Lu X, Liu K, Fu J, Zhu H-L. Synthesis, biological evaluation, and molecular modeling of cinnamic acyl sulfonamide derivatives as novel antitubulin agents. Bioorg. Med. Chem., 19, 4730–4738 (2011).
4. 4) Zhang Z, Meng T, Yang N, Wang W, Xiong B, Chen Y, Ma L, Shen J, Miao Z-H, Ding J. MT119, a new planar-structured compound, targets the colchicine site of tubulin arresting mitosis and inhibiting tumor cell proliferation. Int. J. Cancer, 129, 214–224 (2011).
5. 5) Qian Y, Zhang H-J, Lv P-C, Zhu H-L. Synthesis, molecular modeling and biological evaluation of guanidine derivatives as novel antitubulin agents. Bioorg. Med. Chem., 18, 8218–8225 (2010).
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