Metabolic Suppression by 3-Iodothyronamine Induced Muscle Cell Atrophy <i>via</i> Activation of FoxO–Proteasome Signaling and Downregulation of Akt1

Metabolic Suppression by 3-Iodothyronamine Induced Muscle Cell Atrophy via Activation of FoxO–Proteasome Signaling and Downregulation of Akt1–S6K Signaling

Published:2017 Issue:5 Volume:40 Page:576-582
ISSN:0918-6158
Container-title:Biological & Pharmaceutical Bulletin
language:en
Short-container-title:Biol. Pharm. Bull.

Author:

Ju Hyunwoo¹,Kim Taewan¹,Chung Chan-Moon²,Park Junsoo¹,Nikawa Takeshi³,Park Kyoungsook⁴,Choi Inho¹

Affiliation:

1. Division of Biological Science and Technology, College of Science and Technology, Yonsei University

2. Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University

3. Department of Nutritional Physiology, Institute of Health Biosciences, University of Tokushima Graduate School

4. Sungkyunkwan University School of Medicine

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

https://www.jstage.jst.go.jp/article/bpb/40/5/40_b16-00653/_pdf

Reference32 articles.

1. 1) Fitts RH, Riley DR, Widrick JJ. Functional and structural adaptations of skeletal muscle to microgravity. J. Exp. Biol., 204, 3201–3208 (2001).

2. 2) Du J, Wang X, Miereles C, Bailey JL, Debigare R, Zheng B, Price SR, Mitch WE. Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J. Clin. Invest., 113, 115–123 (2004).

3. 3) Zurlo F, Larson K, Bogardus C, Ravussin E. Skeletal muscle metabolism is a major determinant of resting energy expenditure. J. Clin. Invest., 86, 1423–1427 (1990).

4. 4) Wijers SL, Saris WH, van Marken Lichtenbelt WD. Recent advances in adaptive thermogenesis: potential implications for the treatment of obesity. Obes. Rev., 10, 218–226 (2009).

5. 5) Ju H, Shin H, Son C, Park K, Choi I. 3-Iodothyronamine-mediated metabolic suppression increases the phosphorylation of AMPK and induces fuel choice toward lipid mobilization. Horm. Metab. Res., 47, 605–610 (2015).

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Ang-1 and VEGF: central regulators of angiogenesis;Molecular and Cellular Biochemistry;2024-04-23

2. The 3-iodothyronamine (T1AM) and the 3-iodothyroacetic acid (TA1) indicate a novel connection with the histamine system for neuroprotection;European Journal of Pharmacology;2021-12

3. Commentary: Euthyroid Sick Syndrome in Patients With COVID-19;Frontiers in Endocrinology;2021-02-10

4. THE METABOLIC SUPPRESSOR 3-IODOTHYRONAMINE ENHANCES LIPOLYSIS IN 3T3-L1 ADIPOCYTES VIA ACTIVATION OF THE ADENOSINE MONOPHOSPHATE- ACTIVATED PROTEIN KINASE/FORKHEAD BOX 01 SIGNALING PATHWAY;J PHYSIOL PHARMACOL;2020

5. Thyroid Hormone Metabolite 3-Iodothyronamine (T1AM) Alleviates Hypoxia/Reoxygenation-Induced Cardiac Myocyte Apoptosis via Akt/FoxO1 Pathway;Medical Science Monitor;2020-03-06