Synthesis of the Key Intermediate, Diethyl 2-Acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the Immunomodulatory Agent FTY720 (Fingolimod)-Reference-Cited by-同舟云学术

Synthesis of the Key Intermediate, Diethyl 2-Acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the Immunomodulatory Agent FTY720 (Fingolimod)

Published:2008 Issue:4 Volume:56 Page:595-597
ISSN:0009-2363
Container-title:Chemical and Pharmaceutical Bulletin
language:en
Short-container-title:CHEMICAL & PHARMACEUTICAL BULLETIN

Author:

Matsumoto Norimasa¹,Hirose Ryoji¹,Sasaki Shigeo¹,Fujita Tetsuro²

Affiliation:

1. Research Laboratory, Taito Co., Ltd.

2. Faculty of Pharmaceutical Sciences, Setsunan University

Publisher

Pharmaceutical Society of Japan

Subject

Drug Discovery,General Chemistry,General Medicine

Link

http://www.jstage.jst.go.jp/article/cpb/56/4/56_4_595/_pdf

Reference34 articles.

1. 1) Present address: Fukuoka Factory, Production Group, Mitsui Sugar Co., Ltd.; 6-11-30 Hakozakifuto, Higashi-ku, Fukuoka 812-0051, Japan.

2. 2) Present address: Quality Assurance Division, Production Group, Mitsui Sugar Co., Ltd.; 2-8-2 Nihonbashi-Honcho, Chuo-ku, Tokyo 103-8423, Japan.

3. 3) Present address: Research Laboratory, Mitsui Sugar Co., Ltd.; 1-2-14 Honson, Chigasaki, Kanagawa 253-0042, Japan.

4. 4) Present address: Research Institute for Production Development; 15 Shimogamo Morimoto-cho, Sakyo-ku, Kyoto 606-0805, Japan.

5. Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite.

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