Interindividual Variability in 2-Hydroxylation, 3-Sulfation, and 3-Glucuronidation of Ethynylestradiol in Human Liver-Reference-Cited by-同舟云学术

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Interindividual Variability in 2-Hydroxylation, 3-Sulfation, and 3-Glucuronidation of Ethynylestradiol in Human Liver

Published:2004 Issue:12 Volume:27 Page:1900-1906
ISSN:0918-6158
Container-title:Biological and Pharmaceutical Bulletin
language:en
Short-container-title:Biol. Pharm. Bull.

Author:

Shiraga Toshifumi¹,Niwa Toshiro¹²,Ohno Yasuo³,Kagayama Akira¹

Affiliation:

1. Biopharmaceutical and Pharmacokinetic Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

2. Post-marketing Development Research Center, Fujisawa Pharmaceutical Co., Ltd.

3. Division of Pharmacology, Biological Safety Research Center, National Institute of Health Sciences, Japan

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

http://www.jstage.jst.go.jp/article/bpb/27/12/27_12_1900/_pdf

Reference34 articles.

1. Interindividual variation in the metabolism of ethynylestradiol

2. A preliminary report on urinary excretion pattern and method of isolation of 14C-ethynylestradiol metabolites in women

3. Differences in the cytochrome P-450 isoenzymes involved in the 2-hydroxylation of oestradiol and 17 α-ethinyloestradiol. Relative activities of rat and human liver enzymes

4. Metabolism of radioactive 17α-ethynylestradiol by women

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1. Drug Interactions Involving 17α‐Ethinylestradiol: Considerations Beyond Cytochrome P450 3A Induction and Inhibition;Clinical Pharmacology & Therapeutics;2021-08-24

2. Drug‐Drug Interaction Studies With Oral Contraceptives: Pharmacokinetic/Pharmacodynamic and Study Design Considerations;The Journal of Clinical Pharmacology;2020-12

3. The effect of laquinimod, a novel immuno-modulator in development to treat Huntington disease, on the pharmacokinetics of ethinylestradiol and levonorgestrel in healthy young women;European Journal of Clinical Pharmacology;2018-09-06

4. Risk-Benefit Assessment of Ethinylestradiol Using a Physiologically Based Pharmacokinetic Modeling Approach;Clinical Pharmacology & Therapeutics;2018-04-27

5. Effects of Flibanserin on the Pharmacokinetics of a Combined Ethinylestradiol/Levonorgestrel Oral Contraceptive in Healthy Premenopausal Women: A Randomized Crossover Study;Clinical Therapeutics;2018-01

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