Syntheses of potential antimetabolites. XX. Syntheses of 5-carbomethoxymethyl- and 5-methylaminomethyl-2-thiouridine (the "first letters" of some anticodons) and closely related nucleosides from uridine.
Author:
Publisher
Pharmaceutical Society of Japan
Subject
Drug Discovery,General Chemistry,General Medicine
Link
http://www.jstage.jst.go.jp/article/cpb1958/23/11/23_11_2958/_pdf
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1. Protection‐Free, Two‐step Synthesis of C5‐C Functionalized Pyrimidine Nucleosides;Current Protocols;2024-02
2. Two-step conversion of uridine and cytidine to variously C5-C functionalized analogs;Organic & Biomolecular Chemistry;2023
3. Synthesis of 5‐Cyanomethyluridine (cnm 5 U) and 5‐Cyanouridine (cn 5 U) Phosphoramidites and Their Incorporation into RNA Oligonucleotides;Current Protocols in Nucleic Acid Chemistry;2020-08-26
4. Cyano Modification on Uridine Decreases Base‐Pairing Stability and Specificity through Neighboring Disruption in RNA Duplex;ChemBioChem;2018-11-19
5. C5-substituents of uridines and 2-thiouridines present at the wobble position of tRNA determine the formation of their keto-enol or zwitterionic forms - a factor important for accuracy of reading of guanosine at the 3′-end of the mRNA codons;Nucleic Acids Research;2017-01-13
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