Toxicological Property of Acetaminophen: The Dark Side of a Safe Antipyretic/Analgesic Drug?

Author:

Ishitsuka Yoichi1,Kondo Yuki1,Kadowaki Daisuke2

Affiliation:

1. Department of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamoto University

2. Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Sojo University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference154 articles.

1. 1) Brodie BB, Axelrod J. The fate of acetanilide in man. J. Pharmacol. Exp. Ther., 94, 29–38 (1948).

2. 2) Ghanem CI, Pérez MJ, Manautou JE, Mottino AD. Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity. Pharmacol. Res., 109, 119–131 (2016).

3. 3) Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc. Natl. Acad. Sci. U.S.A., 96, 7563–7568 (1999).

4. 4) Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New Biol., 231, 232–235 (1971).

5. 5) Flower RJ, Vane JR. Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature, 240, 410–411 (1972).

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