Reduction in the Doses of Direct Oral Anticoagulants and Risk of Ischemic Stroke Events: A Hospital Survey

Author:

Ueda Aya123,Toki Shinji2,Kitayama Chisato2,Akazawa Manabu3

Affiliation:

1. Nihon Chouzai Co., Ltd.

2. Department of Pharmacy, St. Marianna School of Medicine Hospital

3. Department of Public Health and Epidemiology, Meiji Pharmaceutical University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference19 articles.

1. 1) Barra ME, Fanikos J, Connors JM, Sylvester KW, Piazza G, Goldhaber SZ. Evaluation of dose-reduced direct oral anticoagulant therapy. Am. J. Med., 129, 1198–1204 (2016).

2. 2) Nielsen PB, Skjøth F, Søgaard M, Kjældgaard JN, Lip GY, Larsen TB. Effectiveness and safety of reduced dose non-vitamin K antagonist oral anticoagulants and warfarin in patients with atrial fibrillation: propensity weighted nationwide cohort study. BMJ, 356, j510 (2017).

3. 3) Okumura Y, Yokoyama K, Matsumoto N, et al. Current use of direct oral anticoagulants for atrial fibrillation in Japan: findings from the SAKURA AF Registry. J. Arrhythm., 33, 289–296 (2017).

4. 4) Yamashita Y, Uozumi R, Hamatani Y, Esato M, Chun YH, Tsuji H, Wada H, Hasegawa K, Ogawa H, Abe M, Morita S, Akao M. Current status and outcomes of direct oral anticoagulant use in real-world atrial fibrillation patients—Fushimi AF Registry. Circ. J., 81, 1278–1285 (2017).

5. 5) Granger CB, Alexander JH, McMurray JJ, et al. Apixaban versus warfarin in patients with atrial fibrillation. N. Engl. J. Med., 365, 981–992 (2011).

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